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为了观察方克同步放射治疗老年食管癌的疗效及不良反应。将40例>70岁老年食管癌患者分为两组,增敏组20例和单放组20例。放疗采用6MV或15MVX线,常规分割放疗。1·8~2·0Gy/次,5次/周,总剂量55~65Gy/5~7周完成。放疗同步使用方克小剂量0·7g加入生理盐水500mL,静脉滴入,每周一至五,直至放疗结束。结果增敏组与单放组有效率分别为90·0%(18/20)和50·0%(10/20),两组比较差异有统计学意义,χ2=7·62,P=0·006;1、2和3年生存率增敏组分别为80%(16/20)、50%(10/20)和35%(7/20);单放组分别为40%(8/20)、20%(4/20)和5%(1/20),两组比较差异有统计学意义,χ2值分别为6·67、3·96和3·91,P值分别为0·009、0·048和0·049。增敏组发生急性消化道反应和白细胞下降高于单放组,多数为1~2级。初步研究结果提示,方克联合放疗方案安全、耐受性好,疗效佳。
In order to observe the efficacy and side effects of radiofrequency radiation therapy for esophageal cancer in the elderly. Forty patients with> 70 years old esophageal cancer were divided into two groups: 20 in sensitization group and 20 in radiotherapy alone group. Radiotherapy using 6MV or 15MVX lines, conventional radiotherapy. 1.8-8.0Gy / time, 5 times / week, the total dose of 55 ~ 65Gy / 5 ~ 7 weeks to complete. Radiotherapy concurrent use of small doses of 0.7 grams of normal saline 500mL, intravenous infusion, one to five weeks a week until the end of radiotherapy. Results The effective rates in sensitized and untreated groups were 90.0% (18/20) and 50.0% (10/20), respectively, with significant difference between the two groups (χ2 = 7.22, P = 0 · The rates of 1, 2, and 3-year survival were 80% (16/20), 50% (10/20) and 35% (7/20) 20), 20% (4/20) and 5% (1/20) respectively. The difference between the two groups was statistically significant (χ2 = 6.67, 3.96 and 3.91, P = 0 · 009, 0 · 048 and 0 · 049. In the sensitized group, the incidence of acute digestive tract reaction and leukopenia were higher than those in the radiotherapy alone group, most of whom were grade 1 ~ 2. Preliminary findings suggest that Fang Ke combined radiotherapy program safe, well tolerated, good effect.