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目的探讨胰腺癌甾体激素受体状态及其生物学特征。方法采用Ｓ－Ｐ免疫组化方法对５０例胰腺导管腺癌雌激素受体（ＥＲ）、孕激素受体（ＰＲ）进行检测。结果胰腺导管腺癌ＥＲ阳性率５０．０％（２５／５０）ＰＲ阳性率４６．０％（２３／５０）。ＥＲ、ＰＲ状态与癌组织的分化程度密切相关（Ｐ＜０．０１），癌组织分化越好，ＥＲ、ＰＲ水平越高。无转移的胰腺癌ＥＲ水平高于有转移灶者（Ｐ＜０．０５）。ＥＲ、ＰＲ水平与性别、年龄、ＴＭＭ分期均无明显关系（Ｐ＞０．０５）。结论胰腺癌组织内存在ＥＲ、ＰＲ，其水平反映了胰腺癌的生物学特性
Objective To investigate the status of steroid hormone receptor in pancreatic cancer and its biological characteristics. Methods S-P immunohistochemistry was used to detect 50 cases of estrogen receptor (ER) and progesterone receptor (PR) of ductal adenocarcinoma of the pancreas. Results The positive rate of ER in pancreatic ductal adenocarcinoma was 50.0% (25/50). The positive rate of PR was 46.0% (23/50). The ER and PR status were closely related to the degree of differentiation of cancer tissues (P<0.01). The better the cancer tissue differentiation, the higher the ER and PR levels. The metastasis-free pancreatic cancer ER levels were higher than those with metastases (P<0.05). There was no significant relationship between ER and PR levels and sex, age and TMM staging (P>0.05). Conclusions ER and PR exist in pancreatic cancer tissues, and their levels reflect the biological characteristics of pancreatic cancer.