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应用日本血吸虫单克隆抗独特型抗体ＮＰ３０腹腔注射致敏Ｃ５７ＢＬ／６小鼠，继之经脾脏注射虫卵形成的肝虫卵肉芽肿模型。用ＳＥＡ致敏组作阳性对照，ＳＰ２／０腹水组作阴性对照。实验结果表明，在虫卵攻击后第４ｄ，ＮＰ３０致敏组肝虫卵肉芽肿面积、体积即开始明显增加，出现多量嗜酸性粒细胞浸润。肉芽肿面积在第８ｄ、体积在第１５ｄ达高峰值，与ＳＥＡ致敏组的高峰值相近（Ｐ＞０．０５）。而ＳＰ２／０腹水组肉芽肿的面积、体积至第３２ｄ才达高峰值，其高峰值低于ＮＰ３０致敏组（面积Ｐ＜０．０５，体积Ｐ＜０．０１）。本文提示ＮＰ３０对肝虫卵肉芽肿的形成具有致敏作用。
The C57BL / 6 mice were sensitized by intraperitoneal injection of the monoclonal anti-idiotypic antibody NP30 of Schistosoma japonicum, followed by injection of the spleen into the hepatic worm egg granuloma model. SEA sensitized group as positive control, SP2 / 0 ascites group negative control. The experimental results showed that on the 4th day after the egg attack, the area and volume of hepatic worm granuloma in NP30 sensitized group began to increase obviously, and a large amount of eosinophil infiltration occurred. On the 8th day, the area of granuloma reached a peak on the 15th day, which was similar to that of the SEA sensitized group (P> 0.05). The area of granuloma in SP2 / 0 ascites group reached the peak value at the 32nd day, and its peak value was lower than that of NP30 sensitized group (P <0.05, P <0.01). This paper suggests that NP30 has a sensitizing effect on the formation of hepatic worm egg granuloma.