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我们用大剂量维生素B_6抢救急性异菸肼(INH)中毒,疗效较好。笔者根据临床经验提出“维生素B_6显效化”做为给药指标,易于掌握,报道如下: 本组13例,均有明确服异菸肼过量史,症状典型,诊断为急性INH中毒。抢救方法:就诊后常规洗胃、导泻。并采取以下措施:首剂静脉推注维生素B_6500毫克。双管输液:一管用5.5号针头静滴0.1％维生素B_6 (10％葡萄糖500毫升+2.5％维生素B_6 1毫升×20支)。另一管用8号针头快速输入含糖盐水或林格氏液。输液后注速尿20～40毫克。就诊后每惊厥一次静注维生素B_6250毫克。惊厥是再次静注维生素B_6的指征,惊厥发作停止是“维生素B_6显效化”的指标。必须强调,关键在于前30分钟内达到显效化。12小时输
We use large doses of vitamin B_6 rescue acute isoniazid (INH) poisoning, better effect. The author based on clinical experience, “vitamin B_6 markedly effective” as a drug target, easy to grasp, are reported as follows: The group of 13 patients, both clear overdose of isoniazid with history, typical symptoms, diagnosis of acute INH poisoning. Rescue methods: After treatment, regular gastric lavage, catharsis. And take the following measures: The first intravenous bolus vitamin B_6500 mg. Double infusion: a tube with a 5.5 needle intravenous infusion of 0.1% vitamin B_6 (10% glucose 500 ml + 2.5% vitamin B_6 1 ml × 20). Another tube with a quick 8 needle input saline or Ringer’s solution. Infusion after injection speed urine 20 ~ 40 mg. After treatment for each convulsion once intravenous vitamin B_6250 mg. Convulsive is the indication of intravenous vitamin B_6 intravenously, and the seizure stop is an indicator of “vitamin B_6 visualization”. It must be emphasized that the key is to achieve the first 30 minutes to achieve a significant effect. 12 hours lose