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系统性红斑狼疮（ＳＬＥ） 是一种针对自身细胞核抗原的免疫性疾病，其核抗原中最主要的包括核小体复合物、组蛋白和ＤＮＡ。细胞程序性死亡或凋亡的特征是将细胞核染色质裂解为寡聚核小体，然后将其释放到细胞外空间。这些核小体是否作为免疫原驱动自身免疫反应；ＳＬＥ患者外周血淋巴细胞凋亡是否与ＳＬＥ的发病有关，本文就ＳＬＥ细胞凋亡与自身抗原来源之间的关系作一综述。
Systemic lupus erythematosus (SLE) is an autoimmune disease that targets its own nuclear antigens, the most important of which include nucleosome complexes, histones and DNA. A feature of programmed cell death or apoptosis is the cleavage of nuclear chromatin into oligomeric nucleosomes which are then released into the extracellular space. Whether these nucleosomes serve as immunogens to drive the autoimmune response; whether peripheral blood lymphocyte apoptosis in SLE patients is related to the pathogenesis of SLE, we review the relationship between SLE apoptosis and the origin of autoantigens.