,The Intrinsically Disordered Protein BKI1 Is Essential for Inhibiting BRI1 Signaling in Plants

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Dear Editor,Brassinosteroids (BRs) are a class of essential polyhydroxylated steroid hormones regulating plant growth and development,and their responses to environmental cues (Clouse,2011;Yang et al.,2011).BRs are perceived at the plasma membrane by a receptor complex,which consists of two leucine-rich receptor-like kinases (LRR-RLKs),BRASSINOSTEROID INSENSITIVE 1 (BRI1) and BRI1-ASSOCIATED RECEPTOR KINASE 1 (BAK1).When activated by BRs,the receptor complex initiates a cascade of multiple kinases and phosphatases,ultimately leading to the dephosphorylation and activation of a family of closely related transcription factors,including BRI1-EMS SUPPRESSOR1 (BES1) and BRASSINAZOLE-RESISTANT1 (BZR1),to regulate the expression of thousands of target genes (Guo et al.,2013).
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