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癫痫是常见病、慢性病,其发病机理及抗癫痫药物作用机理尚未完全明了,因而治疗上存在着严重的混乱现象。例如,有些医生的治疗方法是:多药联用,通常3～5种,有的竟多达12种;不分个体特点,每种药物一律给予“常规剂量”;一日3～4次服用。这样的给药方案增加了药物间的相互反应,不能判断药物剂量的个体差异,也不能预测和避免长期治疗中的慢性中毒问题。近十年来,随着药物动力学及化学测定新技术的进展,抗癫痫药物血浓度测定在世界范
Epilepsy is a common disease, chronic diseases, its pathogenesis and anti-epileptic drugs mechanism of action is not yet fully understood, and therefore there is a serious treatment of chaos. For example, some doctors treat multiple drug combinations, usually 3-5, and some as many as 12; regardless of individual characteristics, each drug is given a “regular dose”; 3 to 4 times daily . Such dosing regimens increase inter-drug interactions, fail to determine individual differences in drug dosage, and can not predict and avoid chronic poisoning problems in long-term treatment. Over the past decade, with the development of new technologies of pharmacokinetics and chemical determination, the antiepileptic drug blood concentration was measured in the world