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目的:分析头孢拉定静脉滴注致儿童血尿的原因。方法:收集2005年3月至2008年3月社区使用头孢拉定致19例儿童血尿的临床资料。对患者的性别、年龄及临床表现,头孢拉定的用法用量,血尿出现的时间和严重程度以及转归进行调查分析。结果:19例患儿中男16例,女3例,年龄≤1岁3例,～3岁10例,～7岁4例,>7岁2例。头孢拉定常规用法用量为50～100mg/(kg.d)溶于0.9%氯化钠或5%葡萄糖注射液100～250ml中静脉滴注。剂量为100mg/(kg.d)16例,>110mg/(kg.d)1例,<100mg/(kg.d)2例。有17例将1日剂量作1次量给予。19例中,肉眼血尿17例,镜下血尿2例。实验室检查示红细胞(+++～++++)/HP,尿蛋白定量<0.1g/24h。肾功能正常者16例(84.2%),肌酐、尿素氮轻度升高者3例(15.8%)。血尿出现于用药后24h内18例(94.7%),>24h1例(5.3%)。经停药治疗后,肉眼血尿于1～2d消失,镜下血尿于3～5d消失。出院随访3个月,患者尿常规与肾功能均正常。结论:头孢拉定静脉滴注致儿童血尿可能与大剂量、高浓度及低年龄等因素有关
Objective: To analyze the causes of cefradine-induced intravenous drip in children with hematuria. Methods: The clinical data of 19 children with hematuria induced by cefradine from March 2005 to March 2008 were collected. The patient’s gender, age and clinical manifestations, the amount of cefradine use, the time and severity of hematuria, as well as the outcome of the investigation and analysis. Results: There were 16 males and 3 females in 19 cases, 3 cases were ≤1 years old, 10 cases were ~ 3 years old, 4 cases were ~ 7 years old and 2 cases were> 7 years old. Cefradine conventional dosage 50 ~ 100mg / (kg.d) dissolved in 0.9% sodium chloride or 5% glucose injection of 100 ~ 250ml intravenous infusion. One dose of 100mg / (kg.d) in 16 cases,> 110mg / (kg.d) in 1 case, <100mg / (kg.d) in 2 cases. There are 17 cases of the 1st dose for 1 dose. In 19 cases, 17 cases of gross hematuria and 2 cases of microscopic hematuria. Laboratory tests showed red blood cells (+++ ~ ++++) / HP, urine protein quantitation <0.1g / 24h. 16 cases (84.2%) had normal renal function, 3 cases (15.8%) had mild creatinine and slight increase of urea nitrogen. Hematuria appeared in 18 cases (94.7%) within 24h after treatment and> 24h (5.3%) in 24h. After stopping the treatment, gross hematuria disappeared in 1 ~ 2d, microscopic hematuria disappeared in 3 ~ 5d. Discharged from hospital for 3 months, urinary routine and renal function were normal. Conclusion: The incidence of hematuria in children caused by cefradine infusion may be related to the factors such as high dose, high concentration and low age