阿斯匹林对突发性耳聋患者血浆TXB_2、6-K-PGF_(1a)的影响

• 作 者: 朱洪海 董民声 董明敏 韩崇旭 朱丽雅
• 机 构: 河南医科大学第一附属医院耳鼻咽喉科
• 出 处: 河南医科大学学报
• 发表日期: 1997年01期
• 关键词: 突发性耳聋 K-PGF TXB_2 突聋 动态平衡失调 前列腺素 血栓素 酶标记 感觉神经性聋 董明敏

用酶标记免疫法测定３０例突发性耳聋（突聋）患者发病期血浆血栓素Ｂ２（ＴＸＢ２）和６酮前列腺素Ｆ１ａ（６ＫＰＧＦ１ａ）的含量，并对比不同治疗方法对血浆ＴＸＢ２和６ＫＰＧＦ１ａ的影响。结果：突聋患者ＴＸＢ２、ＴＸＢ２／６ＫＰＧＦ１ａ（Ｔ／Ｐ）比值明显增高，６ＫＰＧＦ１ａ显著降低；阿斯匹林治疗后，ＴＸＢ２及Ｔ／Ｐ比值接近正常水平，６ＫＰＧＦ１ａ无明显变化，常规治疗组各项指标均无显著性变化。提示：突聋患者可能存在Ｔ／Ｐ动态平衡失调，而对Ｔ／Ｐ平衡失调的突聋患者加用阿斯匹林治疗可能提高疗效。

Enzyme-linked immunosorbent assay was used to detect the levels of TXB2 and 6KPGF1a in 30 patients with sudden deafness (sudden deafness) and compared with different treatment methods The impact of plasma TXB2 and 6  K PGF1a. Results: The ratio of TXB2, TXB2 / 6KPGF1a (T / P) in patients with sudden deafness was significantly higher than that in patients with sudden deafness (P <0.05), and the levels of TXB2 and T / P in 6KPGF1a were significantly lower after aspirin treatment K  PGF1a no significant change in the conventional treatment group showed no significant change in all indicators. Prompt: Patients with sudden deafness may have T / P homeostasis, while patients with sudden deafness of T / P balance may be treated with aspirin may improve the efficacy.