论文部分内容阅读
目的:评价经皮射频消融(PRFA)联合无水酒精及热顺铂局部注射消融治疗肝癌的疗效及安全性。方法:2001年2月至2004年9月采用B超引导下PRFA联合无水酒精及热顺铂局部注射治疗肝癌76例109个病灶,原发性肝癌40例,转移性肝癌36例。肿瘤直径1.5～15.0cm,应用RF-2000和10电极LeVeen射频针。对1～2cm的小肿瘤选择Chiba针进行局部注射消融,而对>3cm者应用Quadra-Fuse多位穿刺注射针。结果:PRFA及局部注射消融治疗经过均顺利,并发症4例(5.3%),无相关死亡。随访率96.1%,随访期12～43个月,缓解率(CR+PR)为94.7%。患者1、2、3年生存率分别为96.1%、75.4%和42.9%。结论:PRFA联合局部注射消融是原发性及转移性肝癌的有效微创疗法。
OBJECTIVE: To evaluate the efficacy and safety of percutaneous radiofrequency ablation (PRFA) combined with absolute alcohol and thermo-cisplatin in the local injection ablation of liver cancer. Methods: From February 2001 to September 2004, 76 patients with 109 lesions of liver cancer, 40 patients with primary liver cancer and 36 patients with metastatic liver cancer underwent B-ultrasound-guided PRFA combined with anhydrous alcohol and hot cisplatin. Tumor diameter 1.5 ~ 15.0cm, the application of RF-2000 and 10 electrodes LeVeen RF needle. Chiba needles of 1 ~ 2cm small tumors were selected for local injection ablation, while for> 3cm were applied Quadra-Fuse multi-needle. Results: Both PRFA and local injection ablation were successful, with 4 complications (5.3%) and no death related. The follow-up rate was 96.1%. The follow-up period ranged from 12 to 43 months. The response rate (CR + PR) was 94.7%. The 1, 2, 3-year survival rates of patients were 96.1%, 75.4% and 42.9% respectively. Conclusion: PRFA combined with local injection ablation is an effective minimally invasive therapy for primary and metastatic liver cancer.