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目的:探讨与分析米非司酮联合加味竭没散治疗异位妊娠的临床疗效。方法:对采用米非司酮联合加味竭没散治疗的126例异位妊娠病例(观察组)与同期采用MTX 50 mg单次肌注治疗的110例异位妊娠病例(对照组)的治疗效果及不良反应进行比较,采用SPSS 13.0进行统计描述与分析。结果:观察组在1周内症状消失率、3周包块缩小率和血HCG转阴率均明显高于对照组(P<0.05),观察组治愈率91.27%,对照组治愈率为73.63%,差异有统计学意义(P<0.05)。观察组6例服药后出现恶心无呕吐,症状较轻,肝功能异常2例;对照组恶心伴呕吐8例反应较明显,经胃复安等对症治疗缓解,出现肝功能异常4例,全部肝功能异常者均为转氨酶轻度增高,经及时停药并静滴甘利欣等护肝药物治疗后1～2周恢复正常。结论:采用米非司酮联合加味竭没散治疗异位妊娠临床疗效较好,不良反应轻,值得临床推广。
Objective: To investigate and analyze the clinical efficacy of mifepristone combined with Jiawei Fu San to treat ectopic pregnancy. Methods: The therapeutic effect of 126 cases of ectopic pregnancy (observation group) and 110 cases of ectopic pregnancy treated with single intramuscular injection of MTX 50 mg And adverse reactions were compared using SPSS 13.0 statistical description and analysis. Results: The symptom disappearance rate, 3 weeks mass shrinkage rate and HCG negative rate in the observation group were significantly higher than those in the control group (P <0.05). The cure rate in the observation group was 91.27% and that in the control group was 73.63% , The difference was statistically significant (P <0.05). In the observation group, nausea and vomiting occurred in 6 patients with mild symptoms and liver dysfunction in 2 patients. In the control group, the reaction was more obvious in 8 patients with nausea and vomiting. After symptomatic treatment with metoclopramide was relieved, 4 patients showed abnormal liver function, Abnormal function were mildly elevated aminotransferases, after a timely withdrawal and intravenous Gan Lixin and other liver drugs 1 to 2 weeks after treatment returned to normal. Conclusion: The combination of mifepristone and Jiawei Wei San San has better curative effect on ectopic pregnancy and less adverse reactions, which is worthy of clinical promotion.