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目的:观察疏肝健脾汤联合阿德福韦酯治疗拉米夫定耐药的肝郁脾虚型慢性乙型肝炎(CHB)患者的疗效。方法:将80例拉米夫定耐药的CHB肝郁脾虚型患者随机分为疏肝健脾汤组和对照组各40例,对照组采用拉米夫定联合阿德福韦酯片治疗,疏肝健脾汤组在对照组治疗基础上加服疏肝健脾汤,观察两组的临床疗效。结果:疏肝健脾汤组患者治疗后在肝功能复常率、症候改善率、HBV DNA阴转率、细胞免疫功能增强等方面均优于对照组,两组比较差异有统计学意义(P<0.05)。结论:疏肝健脾汤联合阿德福韦酯治疗拉米夫定耐药的肝郁脾虚型CHB患者,具有改善肝功能及临床症候,增强细胞免疫功能从而抑制乙肝病毒复制的临床疗效。
Objective: To observe the curative effect of Shugan Jianpi Decoction combined with adefovir dipivoxil on chronic hepatitis B (CHB) patients with lamivudine resistance. Methods: Eighty patients with lamivudine-resistant CHB liver-qi stagnation and spleen deficiency syndrome were randomly divided into two groups: 40 cases in each group. The control group was treated with lamivudine combined with adefovir dipivoxil, Shuganjianpi Decoction group on the basis of the control group plus Shugan Jianpi Tang, the two groups observed clinical curative effect. Results: After treatment, Shuganjianpi Decoction group was superior to control group in the aspects of the rate of normalization of liver function, the rate of improvement of symptoms, the rate of HBV DNA negative conversion and the enhancement of cellular immunity, and there was significant difference between the two groups (P <0.05). Conclusion: Shuganjianpi Decoction combined with adefovir dipivoxil treatment lamivudine resistant CHB patients with liver depression and spleen deficiency, with improved liver function and clinical symptoms, enhance cellular immune function and thus inhibit the clinical efficacy of hepatitis B virus replication.