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目的探讨呼吸衰竭(Respiratory failure,RF)患者血清甲状腺激素水平的变化及临床意义。方法选择我院呼吸内科呼吸衰竭患者53例,其中急性组患者19例,慢性组34例,健康对照组50例。采用化学发光测定患者空腹血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、高灵敏度促甲状腺激素(hTSH)的水平。结果急、慢性组FT3、FT4间无显著性差异,但均低于正常对照组(P<0.01);急性组hTSH明显低于慢性组和对照组(P<0.01),而慢性组与对照组间无差异(P>0.05)。结论呼吸衰竭患者可表现出甲状腺激素水平减低,甲状腺激素的测定对呼吸衰竭患者疾病的评估具有一定的意义。
Objective To investigate the changes of serum thyroid hormones in patients with respiratory failure (RF) and its clinical significance. Methods 53 cases of respiratory failure in our hospital were selected, including 19 acute patients, 34 chronic patients and 50 healthy controls. Chemiluminescence was used to determine the levels of free triiodothyronine (FT3), free thyroxine (FT4), and hypersensitive thyroid stimulating hormone (hTSH) in fasting serum of patients. Results There was no significant difference between FT3 and FT4 in both acute and chronic groups, but both of them were lower than those in normal control group (P <0.01). HTSH in acute group was significantly lower than that in chronic group and control group (P <0.01) No difference (P> 0.05). Conclusions Patients with respiratory failure may show reduced levels of thyroid hormone. The determination of thyroid hormone may be of value in the assessment of disease in patients with respiratory failure.