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目的:了解某三甲医院药品不良反应(ADR)发生特点及相关因素,为安全用药提供参考。方法:对某三甲医院2010年1月～2011年12月收集的215例ADR报告,按患者情况、给药途径、联合用药情况、药品分布、临床表现等项目进行统计、分析。结果:215例ADR报告共涉及78种药品,抗菌药物构成比最高(55.13%);静脉滴注是引起ADR的主要给药途径(78.60%);临床主要表现为皮肤及附件的损害(52.56%);新的严重的ADR有22例(10.23%)。结论:ADR的发生与多种因素有关,临床应加强ADR监测工作,以减少或避免ADR的发生。
Objective: To understand the characteristics and related factors of adverse drug reaction (ADR) in a top three hospital and provide references for safe medication. Methods: A total of 215 ADR cases collected from a top three hospital from January 2010 to December 2011 were statistically analyzed according to the patient’s condition, route of administration, combination therapy, drug distribution and clinical manifestations. Results: A total of 78 drugs were involved in 215 ADRs with the highest proportion of antimicrobial agents (55.13%). Intravenous drip was the main route of ADR (78.60%). The main clinical manifestations were skin and accessory lesions (52.56% ); New serious ADR in 22 cases (10.23%). Conclusions: The occurrence of ADR is related to many factors. The monitoring of ADR should be strengthened clinically to reduce or avoid the occurrence of ADR.