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Background Smoking is the major cause of airway inflammation in chronic obstructive pulmonary disease(COPD),and smoking cessation is regarded as one of the important strategies for prevention and treatment of the inflammation.The inflammation of the chronic airway may be present and deteriorated even if the COPD patients stop smoking.Whether and how early smoking cessation affects the progress of inflammation is still obscure.This study was conductedto find the appropriate time for smoking cessation to terminate the airway inflammation in rats with smoke-inducedchronic bronchitis.Methods A rat model of COPD was established by passively inhaling smoke mixture.Fifty-four young maleSprague-Dawley rats were randomly divided into 9 groups with different periods of smoke exposure and different timepoints of cessation.The inflammation markers to be detected included inflammatory cells in the bronchoalveolar lavagefluid(BALF),the myeloperoxidose(MPO)activity,the morphologic changes and the expression of ICAM-1 on the airwayepithelium.Results When smoking was terminated at early stage,the inflammatory markers and related indexes were differentfrom those of the typical chronic bronchitis group(group M7)(P<0.01).The pathologic score of group SC7(2 weeks ofsmoking cessation after occurrence of typical chronic bronchitis)was not different from that of group MT,and the level ofICAM-1 was still up-regulated(compared to group M7,P>0.05).Meanwhile,most of inflammatory cells in BALF wereneutrophils compared to other groups(P<0.01).When smoking was terminated,the MPO activity was significantly lowerthan that of group M7(P<0.01).Conclusions Smoking cessation at early stage can effectively inhibit the inflammatory reaction of COPD.Once chronicbronchitis occurs,little could be improved by smoking cessation.Chin Med J 2007;120(17):1511-1516
Background Smoking is the major cause of airway inflammation in chronic obstructive pulmonary disease (COPD), and smoking cessation is regarded as one of the important strategies for prevention and treatment of the inflammation. The inflammation of the chronic airway may be present and deteriorated even if the COPD patients stop smoking. Whhether and how early early smoking cessation affects the progress of inflammation is still obscure. This study was conducted to find the appropriate time for smoking cessation to terminate the airway inflammation in rats with smoke-induced chronic bronchitis. Methods A rat model of COPD was established by passively inhaling smoke mixture. Fifty-four young male Sprague-Dawley rats were randomly divided into 9 groups with different periods of smoke exposure and different timepoints of cessation. Inflammation markers to be found included inflammatory cells in the bronchoalveolar lavage fluid (BALF ), the myeloperoxidose (MPO) activity, the morphologic changes and the exp ression of ICAM-1 on the airway epithelium. Results when smoking was terminated at early stage, the inflammatory markers and related indexes were differentfrom those of the typical chronic bronchitis group (group M7) (P <0.01). The pathologic score of group SC7 ( 2 weeks ofsmoking cessation after occurrence of typical chronic bronchitis) was not different from that of group MT, and the level of ICAM-1 was still up-regulated (compared to group M7, P> 0.05) .Meanwhile, most of inflammatory cells in BALF Chen smoking was terminated, the MPO activity was significantly lowererthan that of group M7 (P <0.01) .Conclusions Smoking cessation at early stage can effectively inhibit the inflammatory reaction of COPD.Once chronic bronchitis , little could be improved by smoking cessation. Chin Med J 2007; 120 (17): 1511-1516