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母胎界面的免疫耐受对维持正常妊娠至关重要。Toll样受体2(TLR2)和TLR4是机体重要天然免疫受体分子之一,TLR2识别肽聚糖,TLR4识别内毒素脂多糖。通过信号转导机制引起核因子κB(NF-κB)等转录因子的活化并调节肿瘤坏死因子α(TNF-α)、γ干扰素(IFN-γ)和白细胞介素12(IL-12)等的产生。越来越多的证据认为,这些细胞因子与不明原因复发性流产(URSA)Th1/Th2细胞因子失衡密切相关。探讨TLR2和TLR4在胎盘中的表达,及其在URSA中的可能作用。
Immune tolerance at the maternal-fetal interface is crucial to maintaining normal pregnancy. Toll-like receptor 2 (TLR2) and TLR4 are one of the most important natural immune receptor molecules in the body. TLR2 recognizes peptidoglycan and TLR4 recognizes endotoxin lipopolysaccharide. Activation of transcription factors such as nuclear factor kappa B (NF-κB) and regulation of tumor necrosis factor α (TNF-α), interferon-γ (IFN-γ) and interleukin 12 (IL-12) The production. More and more evidence suggests that these cytokines are closely related to the unbalance of Th1 / Th2 cytokines in URSA. To investigate the expression of TLR2 and TLR4 in the placenta and its possible role in URSA.