钯催化手性α-酰氧基芳基乙醇的不对称氢化合成

• 出 处: 有机化学
• 发表日期: 2013年12期
• 关键词: 芳基乙醇 钯催化 不对称 氢化反应 不对称还原 手性试剂 活性分子 药物合成 天然产物 化合物

Angew.Chem.Int.Ed.2013,52,11632~11636手性α-酰氧基芳基乙醇类化合物是广泛存在于天然产物、活性分子和一些药物中的有用骨架,也是一些天然化合物和药物合成中的关键手性中间体.有关该类化合物的合成一直受到人们的关注.目前文献报道其合成方法有:(1)以等物质的量的手性试剂参与的还原反应;(2)酵母或酶催化的不对称还原反应;(3)不对称转移氢化反应.作为不

Angew. Chem. Int. Ed. 2013, 52, 11632-11636 Chiral α-acyloxyaryl ethers are useful skeletons widely found in natural products, active molecules and some drugs, as well as some natural compounds and drugs Synthesis of key chiral intermediates for the synthesis of these compounds has been subject to the people’s attention currently reported in the synthesis of the literature are: (1) the amount of substances such as chiral reagents involved in the reduction reaction; (2) Yeast Or enzyme catalyzed asymmetric reduction reaction; (3) asymmetric transfer hydrogenation reaction