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在常规疗法的基础上加用藻酸双酯钠治疗２２例难治性肾病综合征（ＮＳ）高粘血症患儿，剂量：２～５ｍｇ／（ｋｇ·ｄ），分２～３次口服，连续用１１～１４个月。患儿的血液粘度检测指标（血流变学、血脂和尿纤维蛋白降解产物）较治疗前显著下降（Ｐ＜０．０５，０．０１，０．００１），且明显低于用常规疗法加潘生丁的对照组（Ｐ＜０．０５，＜０．０１）。疗程中，蛋白尿和血尿的反复也明显少于对照组（Ｐ＜０．０１）。提示藻酸双酯钠对儿童难治性ＮＳ高粘血症有较好的疗效。
On the basis of conventional therapy plus sodium alginate in 22 children with refractory nephrotic syndrome (hyperviscosity), the dose: 2 ~ 5mg / (kg · d), orally 2 to 3 times , With 11 to 14 months in a row. Children with blood viscosity test indicators (hemorheology, blood lipids and urinary fibrin degradation products) than before treatment decreased significantly (P <0.05,0.01,0.001), and significantly lower than the conventional therapy plus The control group of dipyridamole (P <0.05, <0.01). Course of treatment, albuminuria and hematuria repeated significantly less than the control group (P <0.01). Tip sodium alginate sodium refractory NS hyperviscosity children have a good effect.