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在广西田阳县中学生中，分６组共６９７人进行了Ｏ_（１３９）型霍乱菌苗与Ｏ１群霍乱菌苗的双盲、有对照的人体反应现场观察。结果表明，不加铝佐剂的Ｏ＿（１３９）型霍乱菌苗及Ｏ１群霍乱菌苗，不论是低剂量组（两剂全程接种４５亿菌体）还是常剂量组（全程接种９０亿）接种人群均可产生１０－２５％的体温呈轻度升高的弱反应，并且同种菌苗的两剂量组的反应率无显著差异；第一剂接种的反应率（１９－２５％）较第二剂接种的（１０－１５％）高（Ｐ＜０．０５）：接种局部反应轻微，只有个别受试者出现直径小于１５ｍｍ的硬结；加佐剂的Ｏ１群吸附霍乱菌苗的反应较其它组强。结果证实甲酵灭活的Ｏ_（１３９）型霍乱菌苗和Ｏ１群霍乱菌苗是安全的，接种人体对之具有良好的耐受性。
A total of 697 middle-school students in Tianyang County of Guangxi were enrolled in a double-blind, controlled human response to O 139 cholera vaccine and O1 cholera vaccine. The results showed that the cholera vaccine of O_ (139) type and the cholera vaccine of O1 group, without aluminum adjuvant, were inoculated either in the low-dose group (4.5 billion cells were inoculated with two doses in a full dose) or in the normal dose group The population showed 10-25% mild body temperature increased weak response, and the same vaccine in two dose groups no significant difference in response rates; the first dose of the response rate (19-25%) compared with the first Two doses (10-15%) were higher (P <0.05): local inoculation was mild with only induration of less than 15 mm in diameter for individual subjects; the response of cholerae to the adjuvanted O1 group was higher than that of the other groups Strong. The results confirmed that the parathyroid-killed O_ (139) cholera vaccine and the O1 cholera vaccine were safe and well tolerated in humans.