论文部分内容阅读
目的探讨肺单纯性磨玻璃影(pGGO)的临床特征、手术方式以及病理类型。方法收集39例pGGO患者的临床资料,回顾性分析患者的性别构成、吸烟状况、手术方式、病灶大小、肿瘤组织学类型、淋巴结转移和预后情况。结果全组女性和不吸烟患者明显多于男性和吸烟患者。39例患者中,接受局部切除(大楔形切除或肺段切除)31例,肺叶切除8例。术后病理学检查显示,非典型性腺瘤样增生11例(28.2%),原位腺癌17例(43.6%),微浸润腺癌4例(10.3%),浸润性腺癌2例(5.1%),良性结节5例(12.8%)。38例术中行淋巴结清扫或采样,患者均无淋巴结转移。病灶进展组与病灶无进展组、病灶最大径>1 cm组与病灶≤1 cm组,浸润性病变比例分别为50%、9.1%(P=0.036)和25%、8.7%(P=0.205)。术后随访2~45个月,所有患者均生存,无肿瘤复发及远处转移。结论 pGGO多发于不吸烟女性。pGGO病灶最大径>1 cm且病灶随访不缩小、或随访过程中病灶出现进展时应尽早手术治疗。电视胸腔镜局部切除pGGO的短期治疗效果良好。
Objective To investigate the clinical features, surgical methods and pathological types of lung pGGO. Methods The clinical data of 39 patients with pGGO were collected. The gender composition, smoking status, operation method, tumor size, histological type, lymph node metastasis and prognosis were retrospectively analyzed. Results The whole group of women and non-smoking patients were significantly more than men and smokers. Among the 39 patients, 31 underwent partial resection (large wedge resection or segmentectomy) and 8 lobectomy. Postoperative pathological examination showed that atypical adenomatous hyperplasia was found in 11 cases (28.2%), in situ adenocarcinoma in 17 cases (43.6%), microinvasive adenocarcinoma in 4 cases (10.3%) and invasive adenocarcinoma in 2 cases (5.1% ), Benign nodules in 5 cases (12.8%). Thirty-eight patients underwent lymphadenectomy or sampling without lymph node metastasis. The progression of the lesion group and no progress of the lesion group were 50%, 9.1% (P = 0.036) and 25%, 8.7% (P = 0.205), respectively. . All the patients survived without recurrence and distant metastasis after 2 ~ 45 months follow-up. Conclusion pGGO is more common in non-smokers. The maximum diameter of pGGO lesions> 1 cm and follow-up lesion does not shrink, or follow-up of the progress of lesions should be as soon as possible surgical treatment. Video thoracoscopic partial excision of pGGO short-term treatment is good.