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目的观察奥美拉唑、阿莫西林、甲硝唑组成的三联疗法对胃、十二指肠溃疡的治疗效果。方法把近4 a来在儋州市新州镇新英卫生院门诊及住院治疗的胃、十二指肠溃疡患者126例,随机分为治疗组和对照组,治疗组66例,采用奥美拉唑、阿莫西林、甲硝唑组成的三联疗法治疗;对照组60例,采用雷尼替丁、呋喃唑酮、甲硝唑组成的三联疗法治疗。两组患者均于6周后复查胃镜。用有效率作为评定疗效的指标。结果由奥美拉唑、阿莫西林、甲硝唑组成的三联疗法治疗胃、十二指肠溃疡有效率显著高于由雷尼替丁、呋喃唑酮、甲硝唑组成的三联疗法。结论由奥美拉唑、阿莫西林、甲硝唑组成的三联疗法治疗胃、十二指肠溃疡有效率高,是治疗胃、十二指肠溃疡的最佳组合,值得在临床推广使用。
Objective To observe the therapeutic effect of triple therapy consisting of omeprazole, amoxicillin and metronidazole on gastric and duodenal ulcer. Methods In the past 4 years, 126 patients with gastric ulcer and gastric ulcer in outpatient and inpatient hospital of Xinying Hospital, Xinzhou Town, Pizhou City were randomly divided into treatment group and control group, with 66 cases in treatment group. The combination therapy of lazole, amoxicillin and metronidazole; the control group of 60 patients treated with triple therapy of ranitidine, furazolidone and metronidazole. Two groups of patients were reviewed after 6 weeks endoscopy. Use efficiency as an indicator of efficacy. Results The combination therapy of omeprazole, amoxicillin and metronidazole was effective in the treatment of stomach and duodenal ulcer. The effective rate of duodenal ulcer was significantly higher than that of triple therapy with ranitidine, furazolidone and metronidazole. Conclusions Triple therapy, consisting of omeprazole, amoxicillin and metronidazole, is effective in treating stomach and duodenal ulcer and is the best combination for treating gastric and duodenal ulcer. It is worthy of clinical application.