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[目的 ] 阐明乙型肝炎病毒慢性感染基础对散发性戊型肝炎临床表现、肝功能指标、血清学规律和预后的影响。 [方法 ] 比较分析 10 0例慢性乙型肝炎重叠散发性戊型肝炎患者和 144例散发性戊型肝炎患者的发病年龄、住院时间 ;血清丙氨酸转氨酶 (ALT)、总胆红素 (TB)、谷氨酰转肽酶 (GGT )、碱性磷酸酶 (AKP)和凝血酶原时间(PT)的水平 ;不同病周的抗 -HEV -IgM、抗 -HEV -IgG的阳性率 ;以及病死率。[结果 ] 慢性乙型肝炎重叠散发性戊型肝炎组患者的发病年龄、1～ 2、3～ 4病周的抗 -HEVIgG和 5～ 2 6病周的抗 -HEVIgM、IgG阳性率均明显低于散发性戊型肝炎组 ,而住院时间 ,TB、GGT、AKP和PT水平和病死率明显高于散发性戊型肝炎组患者 (P <0 0 5～0 0 1)。 [结论 ] 乙型肝炎病毒的慢性感染基础使散发性戊型肝炎患者的发病年龄降低、住院时间延长、肝内瘀胆明显、病情加重和预后变差 ;而且 ,缩短抗 -HEV -IgM在恢复期的持续时间和降低抗 -HEV -IgG阳性率
[Objective] To clarify the effect of chronic hepatitis B virus infection on the clinical manifestations, liver function, serological rules and prognosis of sporadic hepatitis E. [Methods] The age of onset and length of hospital stay of 10 patients with overlapping hepatitis B and 144 patients with sporadic hepatitis E were compared and analyzed. Serum levels of alanine aminotransferase (ALT), total bilirubin (TB) ), Glutamyl transpeptidase (GGT), alkaline phosphatase (AKP) and prothrombin time (PT); the positive rates of anti-HEV-IgG and anti-HEV-IgG in different disease weeks; Case fatality rate. [Results] The age of onset of hepatitis B patients with overlapping hepatitis B, anti-HEVIgG at 1-2 and 4 ~ 4 weeks and anti-HEVIgM and IgG at 5 ~ 26 weeks were significantly lower In sporadic hepatitis E group, the hospital stay, TB, GGT, AKP and PT levels and mortality were significantly higher than those in sporadic hepatitis E group (P <0.05-0.01). [Conclusion] The basis of chronic infection of hepatitis B virus is to reduce the age of onset of sporadic hepatitis E patients, prolong the length of hospital stay, obvious liver stasis, aggravation of disease and poor prognosis. Moreover, shortening the anti-HEV-IgM recovery Duration of treatment and decrease of anti-HEV-IgG positive rate