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本文报告用多氯联苯(PCB)200mg/kg对大鼠连续腹腔注射三日染毒,除可诱导肝脏微粒体乙氧基异吩噁唑脱乙基酶(EROD)活性增高外,在脾脏微粒体内也检出EROD活性(4.9pmol/min·mg蛋白质)。当PCB剂量为400mg/kg时,大鼠脾脏S_9组分中EROD活性为对照组的3.3倍。结果说明尽管脾脏本底的细胞色素P-448活性极低,但仍可被化学致癌物PCB诱导。
In this paper, continuous intraperitoneal injection of PCBs (200mg / kg) for three days in mice was used. In addition to increasing the activity of hepatic microsomal ethoxylated isoxazole edetate (EROD) EROD activity was also detected in microsomes (4.9 pmol / min · mg protein). When the PCB dose was 400 mg / kg, the activity of EROD in spleen S_9 of rats was 3.3 times that of the control. The results indicate that although spleen background cytochrome P-448 activity is very low, but can still be induced by the chemical carcinogen PCB.