论文部分内容阅读
目的:研究米非司酮对子宫肌瘤及子宫肌层组织中Caspase-3与Survivin表达的影响。方法:2009年2月～2010年2月于宁波市北仑区人民医院妇科门诊就诊且有手术指征的80例子宫肌瘤患者分为低剂量组和高剂量组,每组各40例。两组患者术前分别服用米非司酮10 mg/d和20 mg/d,共12周。采用彩色多普勒超声测量用药前后的肌瘤体积,术后用免疫组化技术检测子宫肌瘤和子宫肌层组织中Caspase-3与Survivin的表达水平。结果:用药前两组患者的肌瘤体积比较差异无统计学意义(P>0.05);用药后两组患者的肌瘤体积比较差异有统计学意义(P<0.05);两组患者用药前后肌瘤体积比较,差异有统计学意义(P<0.05)。两组子宫肌瘤组织中Caspase-3与Survivin的表达水平比较差异具有统计学意义(P<0.05),而子宫肌层中Caspase-3与Survivin的表达水平比较差异无统计学意义(P>0.05)。结论:米非司酮可抑制子宫肌瘤的生长,可能与增强子宫肌瘤组织中Caspase-3的表达以及降低Survivin的表达有关。
Objective: To study the effect of mifepristone on the expression of Caspase-3 and Survivin in uterine fibroids and myometrium. Methods: From February 2009 to February 2010, 80 patients with uterine fibroids who were treated in gynecology clinic of People’s Hospital of Beilun District, Ningbo City were divided into low dose group and high dose group, 40 cases in each group. Two groups of patients preoperative mifepristone 10 mg / d and 20 mg / d for 12 weeks. The volume of fibroids before and after treatment was measured by color Doppler sonography. The expression of Caspase-3 and Survivin in uterine fibroids and myometrium was detected by immunohistochemistry after operation. Results: There was no significant difference in fibroid volume between the two groups before treatment (P> 0.05). There was significant difference in fibroid volume between the two groups after treatment (P <0.05) Tumor volume, the difference was statistically significant (P <0.05). There were significant differences in the expression levels of Caspase-3 and Survivin between the two groups of uterine fibroids (P <0.05), but there was no significant difference between the expression levels of Caspase-3 and Survivin in the myometrium (P> 0.05 ). Conclusion: Mifepristone can inhibit the growth of uterine fibroids, which may be related to the increase of Caspase-3 expression and the decrease of Survivin expression in uterine fibroids.