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目的 探讨有机氯污染与结直肠癌发病的关系。方法 采用分阶段整群随机抽样的方法,按结直肠癌标化发病率高低在嘉善县抽取11个乡镇,再随机抽取行政村、自然村,采集各自然村的大米和稻田土壤样品,测定其中各有机氯指标的含量,结合各乡镇的结直肠癌发病资料,用Spearman等级相关进行统计分析。结果 大米和土壤中农药六六六(六氯环己烷,HCH)、滴滴涕(二氯二苯三氯乙烷,DDT)含量均未超过国家标准。各乡镇的结直肠癌标化发病率、各乡镇大米中的δ-HCH、γ-HCH、五氯酚钠以及土壤中δ-HCH含量差异存在显著性;结直肠癌标化发病率与大米中总DDT含量、直肠癌标化发病率与大米中总DDT、1,1-双(对-氯苯基)二氯乙烯(PP’-DDE)含量、结肠癌标化发病率与大米中多氯联苯(PCB_s)的1245组分含量之间存在统计学上的显著相关关系,相关系数分别为0.636、0.691、0.716、0.658,P值均<0.05。结论 直肠癌与有机氯农药(主要是大米中总DDT、PP’-DDE)含量存在统计学上显著的相关关系,而结肠癌与大米中PCB_s的1245组分含量存在显著相关关系。但作为生态学研究,其结论还有待于进一步的确证。
Objective To investigate the relationship between organochlorine contamination and colorectal cancer. Methods A total of 11 villages and towns in Jiashan County were selected according to the staged cluster random sampling method. Administrative villages and natural villages were randomly selected to collect rice and paddy soil samples from villages. Chloride content, combined with the incidence of colorectal cancer in towns and villages, with Spearman rank correlation for statistical analysis. Results The contents of hexachlorocyclohexane (HCH) and DDT (DDT) in rice and soil did not exceed the national standards. The incidence of colorectal cancer in each township, the δ-HCH, γ-HCH, sodium pentachlorophenate and δ-HCH in soil of each township were significantly different. The incidence of colorectal cancer was positively correlated with that in rice The total DDT content, the incidence of rectal cancer and the total DDT in rice, the content of 1,1-bis (p-chlorophenyl) ethylene dichloride (PP’-DDE), the incidence of colon cancer, There was a statistically significant correlation between the content of 1245 and biphenyl PCBs. The correlation coefficients were 0.636,0.691,0.716,0.658, P <0.05 respectively. Conclusions There is a statistically significant correlation between rectal cancer and organochlorine pesticides (mainly total DDT and PP’-DDE in rice), while there is a significant correlation between colon cancer and PCBs 1245 in rice. However, as an ecological study, the conclusion remains to be confirmed.