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Purpose: To determine whether motion perception of short-wavelength sensitive(SWS)cones is capable of predicting primary open angle glaucoma (POAG) optic neuropathy.Methods: Motion perceptions of SWS cones were isolated by Blue random dot stimulusdisplayed on the Yellow background, then the detecting displacement threshold of motionperception from SWS cone in POAG was measured, and compared with the age-matchednormal group.Results: The detecting displacement thresholds of motion perception from SWS cones in8 sites of 15 degrees were all elevated in POAG compared with the normal group.Conclusion: These findings suggest that motion perception of SWS cones may revealpreclinical visual nerve damage in early POAG.