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对30例睡前使用中效胰岛素(诺和灵N)的T2DM患者使用CGMS监测完整的两昼夜血糖,换用同等剂量的Glargine,再监测完整的两昼夜。结果使用长效与中效胰岛素期间的夜间血糖值相比在胰岛素剂量小于10单位的患者组无明显差异。大于10单位组,血糖控制更稳定,低血糖的发生率更低。结论长效胰岛素对于空腹血糖(FPG)的控制优于中效,大于10个单位的,长效可进一步平稳控制血糖,减少低血糖的发生。
Thirty patients with T2DM undergoing prerenal use of midazolam (Novolin® N) were monitored for complete diurnal blood glucose with CGMS using the same dose of Glargine for two full days. Results There was no significant difference in the use of long-acting insulin compared with nighttime blood glucose during insulin doses in patients with insulin doses less than 10 units. Greater than 10 units, blood glucose control more stable, lower incidence of hypoglycemia. Conclusion Long-acting insulin is superior to moderate-fast in controlling fasting blood glucose (FPG). If it is longer than 10 units, long-acting insulin can control blood glucose more smoothly and reduce hypoglycemia.