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咳嗽变异性哮喘(CVA)是以咳嗽为唯一或主要表现、不伴明显喘息的特殊类型哮喘,是儿童慢性咳嗽的主要原因之一。CVA的发病机制与典型哮喘相似,呼吸道的慢性炎症和呼吸道重构参与疾病的发生和发展,呼吸道反应性增高是CVA最主要的生理学改变;但CVA与典型哮喘的呼吸道炎症、呼吸道重构严重度和呼吸道反应性可能存在差异。咳嗽敏感性的改变在发病机制中亦可能起一定的作用。
Cough Variant asthma (CVA) is a specific type of asthma that is cough-only or predominantly without wheezing-and is one of the major causes of chronic cough in children. The pathogenesis of CVA is similar to that of typical asthma. Chronic inflammation and respiratory remodeling of the respiratory tract are involved in the occurrence and development of the disease. Increased airway reactivity is the most important physiological change of CVA. However, CVA is associated with respiratory inflammation and respiratory remodeling severity There may be differences in respiratory reactivity. Cough sensitivity changes in the pathogenesis may also play a role.