论文部分内容阅读
应用酶学比色法测定３５例肺心病急性期患者及３０例健康人红细胞膜Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ、Ｃａ２＋－Ｍｇ２＋－ＡＴＰａｓｅ活性，同时测定患者动脉血氧分压（ＰａＯ２）、动脉血二氧化碳分压（ＰａＣＯ２）。结果：患者红细胞膜Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ、Ｃａ２＋－Ｍｇ２＋－ＡＴＰａｓｅ活性下降与对照组比差异十分显著（Ｐ＜０．０１）。患者组Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ、Ｃａ２＋－Ｍｇ２＋－ＡＴＰａｓｅ活性与ＰａＯ２呈显著正相关；与ＰａＣＯ２呈显著负相关。表明：肺心病急性期红细胞膜Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ、Ｃａ２＋－Ｍｇ２＋－ＡＴＰａｓｅ活性下降与严重缺氧、ＣＯ２潴留有关。Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ、Ｃａ２＋－Ｍｇ２＋－ＡＴＰａｓｅ活性下降是引起肺心病急性期细胞内、外离子紊乱的重要因素。
The activities of Na + -K + -ATPase, Ca2 + -Mg2 + -ATPase in 35 patients with acute cor pulmonale and 30 healthy persons were measured by enzyme-linked immunosorbent assay (ELISA). The mean arterial blood pressure (PaO2), arterial carbon dioxide Pressure (PaCO2). Results: The erythrocyte membrane Na + -K + -ATPase, Ca2 + -Mg2 + -ATPase activity decreased significantly compared with the control group (P <0.01). There was a significant positive correlation between the activity of Na + -K + -ATPase, Ca2 + -Mg2 + -ATPase and PaO2 in patients and a significant negative correlation with PaCO2. The results showed that the decrease of Na + -K + -ATPase, Ca2 + -Mg2 + -ATPase activity in erythrocyte membrane in acute cor pulmonale was associated with severe hypoxia and CO2 retention. The decrease of Na + -K + -ATPase and Ca2 + -Mg2 + -ATPase activity is an important factor that causes the disorder of intracellular and extracellular ions in acute phase of pulmonary heart disease.