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1986年Murry等人提出了心肌缺血预适应(或缺血预处理),是指短暂心肌缺血后心肌对其后长时间缺血的适应状态。动物实验已经证实缺血适应可以延迟心肌细胞坏死、缩小心肌梗死范围、降低心律失常发生率[1,2],一些研究表明心肌梗死发病前24-48小时内有心绞痛(AP)发作者预后优于无心绞痛发作者,认为多次不稳定型心绞痛发作也可使缺血心肌处于预适应状态[3]。我们对389例急性心肌梗死(AMI)患者发病前48小时内有无心绞痛发病史进行分析,以探讨心肌缺血对AMI近期预后的影响。
In 1986, Murry et al proposed myocardial ischemic preconditioning (or ischemic preconditioning), which refers to the state of adaptation of the myocardium to subsequent long-term ischemia after transient myocardial ischemia. Animal experiments have shown that ischemic adaptation can delay myocardial necrosis, reduce the scope of myocardial infarction and reduce the incidence of arrhythmia [1,2], some studies have shown that myocardial infarction within 24-48 hours prior to the onset of angina (AP) prognosis In the absence of angina pectoris, that many episodes of unstable angina pectoris can also be ischemic myocardial preconditioning [3]. We analyzed 389 patients with acute myocardial infarction (AMI) patients within 48 hours before the onset of angina pectoris history to analyze the impact of myocardial ischemia on the short-term prognosis of AMI.