论文部分内容阅读
36例镰形细胞贫血患者以前接受过预防性输血。其中14例为女性,1例为成年男性同性恋者。其他患者均无静注药物成瘾史或其他接触乙型肝炎高危因素。这些患者首次接种乙型肝炎疫苗的年龄为1.6～26岁(平均为 14.3岁)。输血时间为1个月～15年(平均6.1年)。用放射免疫法检测免疫前血清抗-HBs和HBsAg,有1例患者HBSAg阳性;5例(15%)患者(包括男性同性恋者)抗-HBs阳性,S/N值≥2.1。 29例患者接种3剂不同批号的疫苗每剂疫苗为0.5ml(20μgHBsAg蛋白),行三角肌注射。第2和第3剂疫苗分别于首次接种后1～
Thirty-six sickle cell anemia patients had previously received prophylactic transfusions. Of these, 14 were female and one was adult male homosexual. Other patients had no history of IV drug addiction or other risk factors for exposure to hepatitis B. The age at first vaccination for hepatitis B in these patients ranged from 1.6 to 26 years (mean, 14.3 years). Transfusion time of 1 month to 15 years (mean 6.1 years). One patient was positive for anti-HBs and HBsAg by radioimmunoassay; 5 (15%) patients (including male homosexuals) were positive for anti-HBs with S / N ≥ 2.1. Twenty-nine patients were vaccinated with three doses of different batches of vaccine 0.5 ml (20 μg HBsAg protein) per dose and deltoid injections. The second and third doses of vaccine were given 1 ~ 1 after the first vaccination