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目的:探讨鼻腔及鼻窦内翻性乳头状瘤临床及病理免疫组织化学参数及其与预后的关系。方法:将52例可随访鼻腔及鼻窦内翻性乳头状瘤病例分成良性组、复发组和恶变组。利用免疫组织化学染色技术检测HPV、MMP-9、PCNA在各组中的表达情况。采用组织学观察、多参数统计学分析方法对52例鼻腔及鼻窦内翻性乳头状瘤的临床特点、病理形态及预后的相关性进行研究。结果:①性别、年龄、病程及肿瘤发生范围比较,三组之间差异无统计学意义;②对临近骨质的侵犯、瘤细胞不典型增生程度及核分裂像多少,恶变组与良性组之间存在统计学差异(P<0.01),但复发组与良性组之间差异无统计学意义;③MMP-9、PCNA在良性组、复发组及恶变组中的高表达率逐渐增强;④HPV感染比较,三组之间存在高度显著差异。结论:综合考虑病理组织学参数可预测鼻腔及鼻窦内翻性乳头状瘤的复发;HPV感染、PCNA和MMP-9的表达可作为判断鼻腔及鼻窦内翻性乳头状瘤发展及预后的参考指标。
Objective: To investigate the clinical and pathological immunohistochemical parameters of inverted papilloma in nasal cavity and nasal sinus and its relationship with prognosis. Methods: 52 cases of nasal and sinus inverted papilloma cases were divided into benign group, relapse group and malignant group. The expression of HPV, MMP-9 and PCNA in each group was detected by immunohistochemical staining. The clinical features, pathological features and prognosis of 52 cases of nasal and sinus inverted papilloma were studied by histological observation and multi-parameter statistical analysis. Results: (1) There was no significant difference in gender, age, course of disease and incidence of tumor between the three groups. (2) Invaded adjacent bone, the degree of atypical hyperplasia of tumor cells and mitotic figures, (P <0.01), but there was no significant difference between the recurrence group and the benign group. (3) The high expression rate of MMP-9 and PCNA gradually increased in benign group, relapse group and malignant group.④Compared with HPV infection, There was a highly significant difference between the three groups. CONCLUSION: Considering the pathological tissue may predict recurrence parameters within the nasal cavity and paranasal sinuses papilloma; of HPV infection, PCNA and MMP-9, and may be determined as the nasal cavity and paranasal sinuses papilloma development and prognosis of the reference .