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目的研究基质金属蛋白酶(MMP)在胃间质瘤(GST)中的表达及其临床意义。方法采用免疫组化方法检测44例 GST 组织中的 MMP-2、MMP-9的表达情况,并分析其与 GST 临床病理之间的关系。结果 GST 组织中的 MMP-2、MMP-9阳性率分别为84.1%、81.8%,MMP-2、MMP-9随着GST 恶性程度增高,其表达出现递增趋势(P<0.05),与肿瘤良恶性、生长方式、肿瘤大小、肿瘤中心有无坏死亦有明显关系(P 均<0.05)。MMP-2与 MMP-9在 GST 中的表达阳性率呈明显正相关关系(r=0.6523,P<0.05)。MMP-2、MMP-9阳性表达者5年生存率显著低于阴性表达者(P 均<0.05)。结论 MMP-2、MMP-9在 GST 中的表达可以作为判断其性质、恶性程度、转移及预后的客观指标。
Objective To study the expression of matrix metalloproteinase (MMP) in gastric stromal tumors (GST) and its clinical significance. Methods The expressions of MMP-2 and MMP-9 in 44 cases of GST were detected by immunohistochemistry, and their relationship with clinicopathological features of GST was analyzed. Results The positive rates of MMP-2 and MMP-9 in GST tissues were 84.1% and 81.8%, respectively. The expressions of MMP-2 and MMP-9 in GST tissues increased with the progression of GST (P <0.05) Malignancy, growth pattern, tumor size and tumor necrosis were also significantly correlated (P <0.05). The positive expression rate of MMP-2 and MMP-9 in GST was positively correlated (r = 0.6523, P <0.05). The 5-year survival rates of MMP-2 and MMP-9 positive patients were significantly lower than those of negative ones (all P <0.05). Conclusion The expression of MMP-2 and MMP-9 in GST can be used as an objective index to judge the nature, malignancy, metastasis and prognosis of GST.