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暴露于有机溶剂可发生有机溶剂中毒性脑病,其神经毒性机制包括溶剂脂溶性、神经递质异常及易感基因携带等。该病临床症状非特异,急性/亚急性中毒主要表现为头痛、共济失调,严重者可致意识障碍,慢性中毒主要表现为注意及执行能力的下降。诊断需结合有机溶剂接触病史、神经心理学测试及必要的影像学检查来综合判定。该病目前缺乏特异性治疗手段,在停止有机溶剂暴露后病情一般没有明显进展。
Exposure to organic solvents can occur organic solvent toxic encephalopathy, its neurotoxic mechanisms include solvent liposolubility, neurotransmitter abnormalities and susceptibility gene carriers. The clinical symptoms of the disease non-specific, acute / subacute poisoning mainly for the headache, ataxia, severe can cause disturbance of consciousness, chronic poisoning mainly for the attention and executive ability decline. Diagnosis should be combined with the organic solvent exposure history, neuropsychological tests and the necessary imaging to comprehensive judgment. The disease is currently lack of specific treatment, the disease was generally no significant progress after the termination of exposure to organic solvents.