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目的探讨苯及其同系物职业接触者血清神经特异性烯化酶(NSE)及髓鞘碱性蛋白(MBP)水平变化。方法采用酶联免疫吸附分析方法,对33例苯及同系物职业危害接触者(其中男性24例,女性9例)和26例正常对照者(其中男9例,女17例)进行血清NSE和MBP的测定。结果接触组血清NSE和MBP水平分别是(13.62±8.76)μg/L、(2.11±0.96)μg/L,显著高于对照组[NSE(8.86±4.49)μg/L、MBP(1.82±0.82)μg/L,P<0.05];接触组和对照组血清NSE异常水平总体概率分布分别为81.8%、15.4%,差异有显著性(P<0.05)。结论苯及同系物接触者血清NSE水平明显升高。
Objective To investigate the changes of serum neuron specific enolase (NSE) and myelin basic protein (MBP) levels in occupational patients with benzene and its homologues. Methods Enzyme linked immunosorbent assay (ELISA) was used to detect the serum levels of NSE in 33 patients with occupational hazards (including 24 males and 9 females) and 26 normal controls (including 9 males and 17 females) Determination of MBP. Results Serum levels of NSE and MBP in the exposure group were (13.62 ± 8.76) μg / L and (2.11 ± 0.96) μg / L respectively, which were significantly higher than those in the control group [NSE (8.86 ± 4.49) μg / μg / L, P <0.05]. The overall probability distributions of serum NSE levels in contact group and control group were 81.8% and 15.4% respectively, with significant difference (P <0.05). Conclusion The levels of serum NSE in benzene and its homologue contacts were significantly increased.