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目的检测慢性头痛患儿血清中弓形虫循环抗原、抗体的感染分布情况,以了解小儿慢性头痛与弓形虫感染的相关性。方法选择152例慢性头痛患儿作为病例组,45例健康体检者作为对照组,分别对其血清弓形虫循环抗原(Cag)、抗体(IgM、IgG)进行检测。结果慢性头痛患儿血清中弓形虫循环抗原抗体检测阳性率为67.10%,高于健康体检组(11.11%),2组阳性率差异有有统计学意义(P<0.01)。慢性头痛组以抗体IgG比例最高,为67.65%(69/102),其中单一IgG为36.27%(37/102),与其他抗原抗体比较,差异具有统计学意义(P<0.05);其次为IgM单独或与IgG、Cag共同存在占55.88%(57/102)。结论本研究提示进行弓形虫抗原抗体检测,对不明原因头痛尤其有宠物接触史的患儿明确病因,指导临床治疗,有一定的应用价值。
Objective To detect the distribution of Toxoplasma gondii circulating antigens and antibodies in serum of children with chronic headache to understand the correlation between chronic headache in children and Toxoplasma gondii infection. Methods A total of 152 children with chronic headache were selected as the case group and 45 healthy controls as the control group. Serum Toxoplasma gondii antigens (Cag) and antibodies (IgM, IgG) were determined. Results The positive rate of Toxoplasma gondii antigen in children with chronic headache was 67.10%, higher than that of the healthy group (11.11%). There was significant difference between the two groups (P <0.01). The ratio of IgG to antibody was the highest in chronic headache group (67.65%, 69/102), and the single IgG was 36.27% (37/102). The difference was statistically significant compared with other antigen and antibody (P <0.05) 55.88% (57/102) either alone or in combination with IgG and Cag. Conclusions This study suggests that Toxoplasma gondii antigen and antibody test may be of certain value in the diagnosis of unexplained headache, especially in the history of pet contact.