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近来,作者选择11例有三年以上系统性红斑狼疮(SLE)病史并符合(1)ARA诊断SLE 4项(或以上)标准,(2)肾活检系活动性肾炎,(3)除阿斯匹林以外,未用皮质激素和免疫抑制剂,(4)类风湿因子阴性。全部患者经肾活检,依据Baldwin氏标准分为:弥漫增殖型肾小球肾炎(DPGN)和局限增殖型肾小球肾炎(FPGN)二型。并用先进的固相放射免疫分析法测其血清DNA抗-DNA免疫球蛋白的结合率,其中包括IgM、IgG、IgA以探访狼疮性肾炎病理类型与抗DNA免疫球蛋白各分量之间的关系。
Recently, the authors selected 11 patients with a history of systemic lupus erythematosus (SLE) for more than three years and met the criteria of (1) ARA diagnosis of SLE 4 items (or more), (2) renal biopsy of active nephritis, (3) Outside the forest, no corticosteroids and immunosuppressive agents, (4) rheumatoid factor negative. All patients were classified by renal biopsy according to Baldwin criteria: diffuse proliferative glomerulonephritis (DPGN) and focal proliferative glomerulonephritis (FPGN) type II. And the use of advanced solid-phase radioimmunoassay to measure the binding rate of serum DNA anti-DNA immunoglobulin, including IgM, IgG, IgA to explore the relationship between pathological types of lupus nephritis and anti-DNA immunoglobulin components.