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目的考察制备的新型棒状羟基喜树碱纳米粒形态的影响因素。方法选择不同投料比、不同制备方法及是否存在其他稳定剂为考察因素,分别进行以新型树枝状大分子PAMAM-co-0.25OEG,PGD为稳定剂的羟基喜树碱纳米粒的制备,并观察纳米粒在电镜下的形态。结果以PGD为稳定剂的羟基喜树碱纳米粒在电镜下的形态不受制备方法的影响,但和药物与稳定剂的比例,即投料比有关,当投料比从4∶1增加至1∶3时,较多PGD稳定剂的存在更容易包裹药物形成球形纳米粒。Chol-PEG600稳定剂与PGD稳定剂同时存在时,高载药量的羟基喜树碱纳米粒中也会存在球形粒子。结论羟基喜树碱纳米粒的形态与稳定剂的用量及其结构有关,且稳定剂性质不同,粒径大小相同的纳米粒电位也相差较大。
Objective To investigate the influencing factors of the morphology of the prepared rod-shaped hydroxycamptothecin nanoparticles. Methods Different feed ratios, different preparation methods and the existence of other stabilizers were selected as the investigation factors. The preparation of hydroxycamptothecin nanoparticles with new dendrimer PAMAM-co-0.25OEG and PGD as stabilizers was performed and observed The morphology of nanoparticles under electron microscopy. Results The morphologies of hydroxycamptothecin nanoparticles with PGD as a stabilizer were not affected by the preparation method under the electron microscope but were related to the ratio of drug to stabilizer, ie, the feed ratio. When the feed ratio increased from 4: 1 to 1: 3, the presence of more PGD stabilizers more easily entrapped drugs to form spherical nanoparticles. When the Chol-PEG600 stabilizer is present in combination with the PGD stabilizer, spherical particles will also be present in the high-loading hydroxycamptothecin nanoparticles. Conclusion The morphology of hydroxycamptothecin nanoparticles is related to the amount of stabilizer and its structure, and the properties of the stabilizer are different. The nanoparticle potentials with the same particle size also differ greatly.