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HBsAg慢性携带者是乙型肝炎的重要传染源,其中少数可导致肝硬化及原发性肝癌的形成。迄今尚无使HBsAg转阴的有效药物,1981年Bassendine氏曾报道阿糖腺苷可抑制HBV的复制。阿糖腺苷联合干扰素多次循环应用可使部份病人DNA多聚酶活力消失,并可消除血液的传染性。但上述药物尚处于试验阶段,药源亦有困难。为筛选其它有效转阴药物,我室于1982年7—9月应用小牛胸腺因子对31例HBsAg慢性携带者转阴效果进行了观察,现报告如下。
Chronic HBsAg carriers are an important source of hepatitis B infection, and a few of them can cause cirrhosis and primary liver cancer. So far there is no effective drug to negative HBsAg, 1981 Bassendine reported that adenosine could inhibit the replication of HBV. Vira adenosine combined with interferon multiple cycles can make part of the DNA polymerase activity of patients disappear, and can eliminate blood contagious. However, the above drugs are still in the experimental phase and their sources of medication are also difficult. In order to screen for other effective negative drugs, my room in July 1982 to July application of calf thymus 31 cases of HBsAg chronic carriers of negative effects were observed, are as follows.