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中国药典1985年版规定庆大霉素的给药方法是“肌内注射或稀释后静脉滴注,一次注射80mg(80000单位),一日2～3次,间隔8h;小儿每公斤体重每日3～5mg(3000～5000单位),分2～3次给。”但在临床上我们经常发现有的护理人员为了图方便或减轻病员多次扎针的痛苦,把庆大霉素不加稀释从莫非氏小壶中直接注入静脉(相当于静脉注射)。笔者曾在健康志愿者进行庆大霉素药动学研究时,对其不同的给药方式进行了比较,发现庆大霉素从小壶给药是不妥当的。现报道如下:
Chinese Pharmacopoeia 1985 edition of gentamicin administration is “intramuscular injection or dilution after intravenous infusion, an injection of 80mg (80,000 units), 2 to 3 times a day, an interval of 8h; children per kilogram of body weight per day 3 ~ 5mg (3000 ~ 5000 units), divided into 2 or 3 times to give. ”But in clinical practice, we often find that some nursing staff in order to facilitate or reduce the patient’s multiple needle acupuncture pain, gentamicin undiluted Into the vein directly from the Moxi cans (equivalent to intravenous injection). When I conducted gentamicin pharmacokinetics studies in healthy volunteers, I compared their different modes of administration and found that it is inappropriate to administer gentamicin from a canister. Reported as follows now: