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目的 探讨利用甘油保存的人羊膜联合自体角膜缘上皮移植，在重建严重碱烧伤后眼表面中的作用。方法 将右眼被碱严重烧伤的新西兰白兔２０只２０眼随机分为３组：甲组６眼，单纯角结膜病灶切除；乙组７眼，联合羊膜移植；丙组７眼，联合羊膜及自体角膜缘上皮移植。结果 术后乙组 １４～１８天（平均 １４．２０天）、两组６～８天（平均７．６０天）角膜表面上皮完全覆盖，二者在术后临床愈合过程中差异有显著性（ Ｐ＜ ０．０５），抑制新生血管的作用丙组优于乙组。结论 人羊膜联合角膜缘上皮移植重建角膜基底膜和角膜缘部结构治疗碱烧伤后的角结膜损伤是一种合理有效的治疗方法。
Objective To investigate the role of human amnion combined with limbal epithelial autograft preserved by glycerol in the ocular surface after severe alkali burn injury. Methods Twenty eyes of 20 New Zealand white rabbits with severe burn in the right eyes were randomly divided into 3 groups: group A (6 eyes), simple keratoconjunctival lesion (group B), group B (7 eyes) combined with amniotic membrane transplantation Autologous limbal epithelial transplantation. Results After operation, group B had complete coverage of corneal surface epithelium 14 to 18 days (average 14.20 days) and complete corneal surface epithelium 6 to 8 days (average 7.60 days). There was significant difference between the two groups in clinical healing P <0.05), the role of inhibiting angiogenesis in group C is better than group B. Conclusion Reconstruction of the corneal basement membrane and corneal limbal epithelium by human amnion combined with limbal epithelial transplantation is a reasonable and effective treatment for the treatment of corneal injury.