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目的探讨新生儿化脓性脑膜炎的临床特点和治疗转归。方法分析42例新生儿化脓性脑膜炎患儿的病原、高危因素、临床特点、实验室检查及治疗转归。结果所有患儿住院时间4～83 d,平均23.1 d。化脓性脑膜炎平均治疗时间24.4 d。痊愈27例,好转11例,死亡1例,放弃治疗3例。共12例存在并发症,脑脊液常规检查细胞总数大于500×106/L、CRP大于100 mg/L者发生并发症的可能性大。结论新生儿化脓性脑膜炎是新生儿严重感染性疾病之一,发生并发症的几率高,提高病原诊断率非常重要,抗菌药物需要根据病原菌药敏试验以及临床经验选用合适抗生素。
Objective To investigate the clinical features and treatment outcome of neonatal purulent meningitis. Methods 42 cases of neonatal purulent meningitis in children with pathogens, high risk factors, clinical features, laboratory tests and treatment outcome. Results All patients were hospitalized for 4 ~ 83 days, an average of 23.1 days. The average duration of purulent meningitis treatment 24.4 d. 27 cases were cured, improved in 11 cases, 1 died, give up treatment in 3 cases. A total of 12 cases of complications, cerebrospinal fluid routine examination of the total number of cells greater than 500 × 106 / L, CRP greater than 100 mg / L, the possibility of complications. Conclusion Neonatal purulent meningitis is one of the most serious neonatal infectious diseases. It is very important to increase the chances of complication and improve the diagnosis rate of pathogens. Antibacterial drugs need appropriate antibiotics according to the susceptibility test of pathogen and clinical experience.