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一氧化氮(NO)-环磷酸鸟苷(cGMP)信号的刺激可导致血管舒张和肌肉葡萄糖摄入(MGU)增加。Ayala JE等人进行了一项研究,观察长期应用磷酸二酯酶-5(PDE_5)抑制剂西地那非通过抑制环磷酸鸟苷水解,是否可以改善由高脂饮食所致胰岛素抵抗大鼠的能量平衡和体内胰岛素活性。对高脂肪喂养大鼠采用西地那非联合L-精氨酸或单用西地那非治疗12周,通过增加能量消耗引起体重下降和减少脂肪堆积。然而在西地那非治疗组中的小鼠体内UCP-1(解偶联蛋白-1)水平并未增加。长期采用西地那非联合L-精氨酸或单
Stimulation of nitric oxide (NO) -cGMP signals can lead to increased vasodilatation and muscle glucose uptake (MGU). Ayala JE, et al. Conducted a study to determine whether long-term use of phosphodiesterase-5 (PDE 5) inhibitor sildenafil inhibited the action of cyclic guanosine monophosphate (glypican) in improving insulin resistance in rats fed high-fat diet Energy balance and in vivo insulin activity. Treatment with sildenafil in combination with L-arginine or sildenafil for 12 weeks in high-fat-fed rats resulted in weight loss and reduced fat accumulation by increasing energy expenditure. However, the level of UCP-1 (uncoupling protein-1) in mice in the sildenafil treatment group did not increase. Long-term use of sildenafil L-arginine or single