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成纤维细胞生长因子21(fibroblast growth factor 21,FGF21)是一种多效应的内分泌因子,主要在肝脏和脂肪组织中分泌,具有降脂、抗炎、抗氧化和抗动脉粥样硬化作用.近年来发现,FGF21在心血管疾病中能够诱导保护作用,心血管疾病患者血浆中FGF21水平升高,可作为亚临床动脉粥样硬化的生物标志物,可作为动脉粥样硬化性心血管疾病的治疗靶点.故本文将对FGF21抗动脉粥样硬化作用的最新进展进行综述.“,”Fibroblast growth factor 21 (FGF21) is a multi-effect endocrine factor, mainly secreted in liver and adipose tissue, with the properties of lipid-lowering, anti-inflammatory, anti-oxidant and anti-atherosclerosis. Recent studies found that FGF21 can induce protective effect in cardiovascular disease, and plasma FGF21 levels in patients with disease cardiovascular are elevated. These studies have suggested the use of FGF21 as a biomarker for subclinical atherosclerosis and its potential role in the treatment of established atherosclerotic cardiovascular disease. This article will review the recent advances in the anti-atherosclerosis effect of FGF21.