Distinctive Drug-resistant Mutation Profiles and Interpretations of HIV-1 Proviral DNA Revealed by D

• 作 者: YIN Qian Qian LI Zhen Peng ZHA
• 机 构: StateKeyLaboratoryofInfectiousDiseasePreventionandControl,StateKeyLaboratoryofInfectiousDiseasePreve
• 出 处: 生物医学与环境科学：英文版
• 发表日期: 2016年4期
• 关键词: 病毒DNA 耐药性监测 逆转录酶 突变谱 显示解 HIV-1 测序 FISHER精确检验 HIV-1 drug-resistant mutation Drug
• 基金项目: ＊This work was supported by grants from the State Key Laboratory of Infectious Disease Prevention and Control （2011SKLID102）, the National Nature Science Foundation of China （81172733 and 81561128006）

Objective To investigate distinctive features in drug-resistant mutations(DRMs) and interpretations for reverse transcriptase inhibitors(RTIs) between proviral DNA and paired viral RNA in HIV-1-infected patients. Methods Forty-three HIV-1-infected individ