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目的验证提踵动作对提高下体负压耐力的有效性,并探讨其可能的作用机制。方法健康男性志愿者10名,在下体负压(LBNP)条件下分别随机进行2次头高位倾斜检查(HUT)测定其下体负压耐力。一次为志愿者的基础下体负压耐力(对照组),另外一次要求志愿者在LBNP条件下做提踵动作,直至耐力终点(提踵组)。结果提踵组下体负压耐受时间(DNP)和累计应激指数(CSI)均显著增加(P<0.05)。在下体负压过程中,提踵组平均动脉压呈升高趋势,心率增加呈降低趋势,每搏量增加,且均在-40 mmHg及-50 mmHg时达到显著水平(P<0.05)。结论提踵动作可以提高下体负压耐力,可望作为航天员在长期太空飞行后引起立位耐力不良时的应对措施,也可作为血管迷走性晕厥患者的预防措施和治疗手段。
Objective To verify the effectiveness of raising heel to improve negative pressure endurance, and to explore its possible mechanism. Methods Ten healthy male volunteers were randomly divided into two groups, under head negative pressure (LBNP) condition, to measure the negative pressure endurance of lower body by HUT. Negative pressure endurance (volunteer) was used as the base of the volunteers, and the other time, volunteers were asked to raise the heels in LBNP until the end of the endurance (heel group). Results The negative pressure tolerance time (DNP) and cumulative stress index (CSI) in lower heel group were significantly increased (P <0.05). In the process of lower body negative pressure, the average arterial pressure in the heel group increased, the heart rate increased and the stroke volume increased, reaching significant levels at -40 mmHg and -50 mmHg (P <0.05). Conclusion The heel movement can improve the negative endurance of the lower body and is expected to be the response measure for the astronauts in the standing position endurance after long-term space flight. It may also be used as a preventive measure and treatment for patients with vasovagal syncope.