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目的:观察盐酸戊乙奎醚对手术患者麻醉期间眼局部瞳孔和眼压的变化和对眼部安全性。方法:46例拟在全麻下行腹腔胆囊切除手术的慢性胆囊炎、胆石症患者,ASAⅠ～Ⅱ级,随机分为盐酸戊乙奎醚组、阿托品组各23例。患者入手术室安静10 min后,记录瞳孔大小作为基础值,用0.4%盐酸奥布卡因滴眼液在左右眼球上各滴1滴进行表麻,2—3 min后测量左右眼球的眼压;在右肩三角肌注射阿托品或盐酸戊乙奎醚。30 min后及清醒30 min后再次记录瞳孔大小和眼压值。结果:在给药30 min后阿托品组双眼眼压都高于盐酸戊乙奎醚组(P<0.05)。两组病人的瞳孔大小基础值无统计学差异,在给药30 min后阿托品组双眼瞳孔都大于基础值(P<0.01),也大于盐酸戊乙奎醚组(P<0.01)。结论:在术前使用盐酸戊乙奎醚不升高眼压,对眼部较为安全。
OBJECTIVE: To observe the changes of eye pupil and intraocular pressure (IOP) and eye safety during the anesthesia of penehyclidine hydrochloride in patients undergoing surgery. Methods: Forty-six patients with chronic cholecystitis and cholelithiasis who underwent abdominal cholecystectomy under general anesthesia were randomly divided into penehyclidine hydrochloride group (n = 23) and atropine group (n = 23). Patients into the operating room was quiet 10 min, the pupillary size was recorded as the baseline value, with 0.4% hydrochloric acid buprenorphine eye drops on the left and right drops of 1 meter ephedra, 2-3 h after the measurement of intraocular pressure In the right shoulder deltoid injection of atropine or penehyclidine hydrochloride. Pupil size and intraocular pressure were recorded again after 30 min and 30 min awake. Results: The intraocular pressure of atropine group was higher than that of penehyclidine hydrochloride group (P <0.05) 30 min after administration. There was no significant difference in pupil size between the two groups. Both pupils of the atropine group were larger than the baseline (P <0.01) and penehyclidine hydrochloride group (P <0.01) 30 min after administration. CONCLUSION: Penehyclidine hydrochloride is not preoperatively used to raise intraocular pressure and is safe for eyes.