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目的比较血清心肌型脂肪酸结合蛋白(H-FABP)检测与常规的检测项目肌酸激酶同工酶(CK-MB)、肌钙蛋白I(cTnI)对于急性心肌梗死(AMI)的诊断效果,探究H-FABP的临床应用价值,以便为AMI的早期诊断提供更好的检测指标。方法本院38例AMI确诊患者作为观察组,43例冠心病患者作为对照组,对所有患者进行全血cTnI、CK-MB质量的测定,对血清中的H-FABP进行定性分析,并进行数据的统计学处理与分析。结果患者入院后的24 h内,H-FABP、CK-MB和cTnI对AMI的敏感度分别为:84.21%、79.07%、76.32%,特异度分别为:100%、76.74%、76.74%;AMI患者胸痛发作6 h内H-FABP的诊断敏感度最高,达到78.26%,其次是CK-MB(73.91%)和cTnI(69.57%)。结论在AMI的早期诊断中,H-FABP检测比CK-MB、cTnI检测具有更好的诊断价值,有望成为临床上AMI早期诊断中有效的检测指标。
OBJECTIVE: To compare the diagnostic value of serum myocardial fatty acid binding protein (H-FABP) test and routine test items of CK-MB and cTnI in patients with acute myocardial infarction (AMI) H-FABP clinical value, in order to provide better detection indicators for the early diagnosis of AMI. Methods 38 patients with AMI diagnosed as observation group and 43 patients with coronary heart disease as control group, all patients were measured cTnI, CK-MB quality, qualitative analysis of H-FABP in serum and data Statistical analysis and treatment. Results The sensitivity of H-FABP, CK-MB and cTnI to AMI were 84.21%, 79.07% and 76.32% within 24 h after admission, respectively. The specificity of AMI was 100%, 76.74% and 76.74% The diagnostic sensitivity of H-FABP in patients with chest pain was the highest (78.26% within 6 h), followed by CK-MB (73.91%) and cTnI (69.57%). Conclusion In the early diagnosis of AMI, H-FABP test has better diagnostic value than CK-MB and cTnI test, which is expected to be an effective detection index in the early diagnosis of AMI in clinic.