人脂肪组织来源间充质干细胞移植在减少动静脉瘘相关性静脉内膜增生的示踪与疗效

• 作 者: B.Yang A.Brahmbhatt E.N.Torres B.Thielen D.L.Mc Call S.Engel 李畅
• 机 构: Vascular and Interventional Radiology Translational Laboratory, Department of Radiology and Departme
• 出 处: 国际医学放射学杂志
• 发表日期: 2016年04期
• 关键词: 动静脉瘘 脂肪组织 间充质干细胞 血管外膜 基因表达 静脉 内膜增生 示踪 小鼠死亡 摘要

摘要目的一是建立动静脉瘘(AVF)B6.Cg-Foxn1nu/J小鼠模型,同时将人脂肪组织来源间充质干细胞(MSC)移植到流出静脉的血管外膜后,研究是否能降低单核细胞趋化蛋白-1(Mcp-1)的基因表达,减少静脉内膜增生。二是利用PET连续21 d示踪~(89)Zr标记的MSC。材料与方法所有动物

Abstract The purpose of this study was to establish an animal model of arteriovenous fistula (AVF) B6.Cg-Foxn1nu / J and to study the feasibility of reducing the number of single-vessel-derived mesenchymal stem cells (MSCs) Gene expression of nuclear chemotactic protein-1 (Mcp-1), reducing venous intimal hyperplasia. The second is PET labeled with ~ (89) Zr using PET for 21 consecutive days. Materials and methods All animals