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目的:研究骨松强骨方对去卵巢大鼠股骨骨密度、骨强度和骨结构的影响。方法:采用去势雌性大鼠作为骨质疏松动物模型,将其分为假手术组,对照组,雌激素组,骨松强骨方低、中、高治疗组。治疗3个月后,检测大鼠骨密度、股骨松质骨显微结构以及股骨的生物力学性能。结果:对照组与假手术组相比骨密度、骨应力、结构强度、弹性模量、骨小梁数目显著降低,骨小梁间隙、骨小梁模型因子显著增高,表明摘去卵巢后成功建立骨质疏松症的病理模型。各治疗组与对照组进行比较,发现雌二醇和骨松强骨方的中剂量、高剂量组均能显著抑制大鼠骨密度降低;雌激素及骨松强骨方可不同程度地提高大鼠骨应力、弹性模量,改善大鼠股骨干骺端骨小梁的显微结构。结论:骨松强骨方对骨质疏松症的治疗具有较好的防治作用,且呈剂量依赖性。通过抑制骨量流失,改善骨小梁微结构,提高股骨强度,从而预防脆性骨折。
Objective: To study the effects of “Gusong Qiangu recipe” on femur bone mineral density, bone strength and bone structure in ovariectomized rats. Methods: Ovariectomized female rats were used as animal models of osteoporosis. The rats were divided into sham-operation group, control group, estrogen group and low-dose, middle-dose and high-dose osteoporosis group. After 3 months of treatment, the bone mineral density, the femoral cancellous bone microstructure and the biomechanical properties of the femur were measured. Results: The bone mineral density, bone stress, structural strength, elastic modulus and the number of trabecular bone were significantly decreased in the control group and the sham operation group. The trabecular bone gap and the trabecular model factor were significantly increased, indicating successful establishment of the ovariectomized group Pathological model of osteoporosis. Each treatment group and control group were compared and found that the estradiol and bone pine Qianggufen middle dose and high dose group can significantly reduce the bone mineral density in rats decreased; estrogen and bone pine gorgonian can increase rats to varying degrees Bone stress, elastic modulus, improve the microstructure of trabecular bone in the metaphyseal femur of rats. Conclusion: Gusongqianggufang has good preventive and therapeutic effects on the treatment of osteoporosis in a dose-dependent manner. By inhibiting bone loss, improve trabecular bone microstructure and improve femoral strength, thus preventing brittle fractures.